USC-OGP 2-DE database Two-dimensional polyacrylamide gel electrophoresis database

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Searching in 'USC-OGP 2-DE database' for entry matching: P14625 USC-OGP 2-DE database:  P14625 P14625 General information about the entry View entry in simple text format Entry name ENPL_HUMAN Primary accession number P14625 integrated into USC-OGP 2-DE database on  January 17, 2017 (release 1) 2D Annotations were last modified on January 17, 2017 (version 1) General Annotations were last modified on  April 5, 2017 (version 2) Name and origin of the protein Description RecName: Full=Endoplasmin; AltName: Full=94 kDa glucose-regulated protein; Short=GRP-94; AltName: Full=Heat shock protein 90 kDa beta member 1; AltName: Full=Tumor rejection antigen 1; AltName: Full=gp96 homolog; Flags: Precursor;. Gene name Name=HSP90B1 Synonyms=GRP94, TRA1 Annotated species Homo sapiens (Human) [TaxID: 9606] Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. References [1]   2D GEL CHARACTERIZATION Author 1., Author 2. Submitted (Mar-2011) to Current 2D PAGE maps for identified proteins How to interpret a protein PLATELET_4-5 {PLATELET 4-5} Homo sapiens (Human)   map experimental info   PLATELET_4-5 MAP LOCATIONS: SPOT OGP-0012: pI=4.80; Mw=114297 SPOT OGP-0013: pI=4.74; Mw=113090 SPOT OGP-0014: pI=4.78; Mw=112491 SPOT OGP-0015: pI=4.91; Mw=109544 SPOT OGP-0016: pI=4.99; Mw=102782 SPOT OGP-0018: pI=4.99; Mw=96438 SPOT OGP-0028: pI=5.04; Mw=83116 SPOT OGP-0096: pI=4.97; Mw=41030 UVEAL_MELANOMA_3-10 {UVEAL MELANOMA 3-10} Homo sapiens (Human)   map experimental info   UVEAL_MELANOMA_3-10 MAP LOCATIONS: SPOT OGP-1106: pI=5.01; Mw=112644 SPOT OGP-1107: pI=6.36; Mw=111581 Cross-references UniProtKB/Swiss-Prot P14625; ENPL_HUMAN. 2D PAGE maps for identified proteins How to interpret a protein map You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw. Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly. Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed. External data extracted from UniProtKB/Swiss-Prot Extracted from UniProtKB/Swiss-Prot, release: 0.0 Entry name ENPL_HUMAN Primary accession number P14625 Secondary accession number(s) Q96A97 Sequence was last modified on  April 1, 1990 (version 1) Annotations were last modified on  March 15, 2017 (version 203) Name and origin of the protein Description RecName: Full=Endoplasmin; AltName: Full=94 kDa glucose-regulated protein; Short=GRP-94; AltName: Full=Heat shock protein 90 kDa beta member 1; AltName: Full=Tumor rejection antigen 1; AltName: Full=gp96 homolog; Flags: Precursor; Gene name Name=HSP90B1 Synonyms=GRP94, TRA1 Encoded on Name=HSP90B1; Synonyms=GRP94, TRA1 Keywords 3D-structure; Acetylation; ATP-binding; Calcium; Chaperone; Complete proteome; Direct protein sequencing; Disulfide bond; Endoplasmic reticulum; Glycoprotein; Nucleotide-binding; Phosphoprotein; Reference proteome; Signal. Copyright Copyrighted by the UniProt Consortium, see http://www.uniprot.org/help/license. Distributed under the Creative Commons Attribution-NoDerivs License Cross-references EMBL X15187; CAA33261.1; -; mRNA EMBL M33716; AAA68201.1; -; Genomic_DNA EMBL BC066656; AAH66656.1; -; mRNA EMBL M26596; AAA58621.1; -; Genomic_DNA EMBL AY040226; AAK74072.1; -; mRNA CCDS CCDS9094.1; -; . PIR A35954; A35954; . RefSeq NP_003290.1; NM_003299.2; . UniGene Hs.192374; -; . PDB 4NH9; X-ray; 2.77 A; A=69-337 PDBsum 4NH9; -; . ProteinModelPortal P14625; -; . SMR P14625; -; . BioGrid 113036; 151; . DIP DIP-36060N; -; . IntAct P14625; 76; . MINT MINT-210408; -; . STRING 9606.ENSP00000299767; -; . BindingDB P14625; -; . ChEMBL CHEMBL1075323; -; . DrugBank DB02935; 1-Methoxy-2-(2-Methoxyethoxy)Ethane; . DrugBank DB02103; 2-Chlorodideoxyadenosine; . DrugBank DB03719; N-Ethyl-5'-Carboxamido Adenosine; . DrugBank DB03758; Radicicol; . DrugBank DB00615; Rifabutin; . GuidetoPHARMACOLOGY 2904; -; . iPTMnet P14625; -; . PhosphoSitePlus P14625; -; . SwissPalm P14625; -; . DMDM 119360; -; . DOSAC-COBS-2DPAGE P14625; -; . OGP P14625; -; . REPRODUCTION-2DPAGE IPI00027230; -; . EPD P14625; -; . PaxDb P14625; -; . PeptideAtlas P14625; -; . PRIDE P14625; -; . TopDownProteomics P14625; -; . DNASU 7184; -; . Ensembl ENST00000299767; ENSP00000299767; ENSG00000166598; . GeneID 7184; -; . KEGG hsa:7184; -; . CTD 7184; -; . DisGeNET 7184; -; . GeneCards HSP90B1; -; . GeneCards MIR3652; -; . H-InvDB HIX0056796; -; . HGNC HGNC:12028; HSP90B1; . HPA CAB005224; -; . HPA HPA003901; -; . HPA HPA008424; -; . MIM 191175; gene; . neXtProt NX_P14625; -; . OpenTargets ENSG00000166598; -; . PharmGKB PA36705; -; . eggNOG KOG0020; Eukaryota; . eggNOG COG0326; LUCA; . GeneTree ENSGT00840000129758; -; . HOGENOM HOG000031988; -; . HOVERGEN HBG007374; -; . InParanoid P14625; -; . KO K09487; -; . OMA RKPADVT; -; . OrthoDB EOG091G0270; -; . PhylomeDB P14625; -; . TreeFam TF105969; -; . Reactome R-HSA-1679131; Trafficking and processing of endosomal TLR; . Reactome R-HSA-3000480; Scavenging by Class A Receptors; . Reactome R-HSA-381183; ATF6 (ATF6-alpha) activates chaperone genes; . Reactome R-HSA-6785807; Interleukin-4 and 13 signaling; . ChiTaRS HSP90B1; human; . GeneWiki HSP90B1; -; . GenomeRNAi 7184; -; . PMAP-CutDB P14625; -; . PRO PR:P14625; -; . Proteomes UP000005640; Chromosome 12; . Bgee ENSG00000166598; -; . CleanEx HS_HSP90B1; -; . ExpressionAtlas P14625; baseline and differential; . Genevisible P14625; HS; . GO GO:0005829; C:cytosol; IDA:UniProtKB; . GO GO:0071682; C:endocytic vesicle lumen; TAS:Reactome; . GO GO:0005783; C:endoplasmic reticulum; TAS:UniProtKB; . GO GO:0034663; C:endoplasmic reticulum chaperone complex; IEA:Ensembl; . GO GO:0005788; C:endoplasmic reticulum lumen; IDA:UniProtKB; . GO GO:0005789; C:endoplasmic reticulum membrane; IDA:UniProtKB; . GO GO:0070062; C:extracellular exosome; IDA:UniProtKB; . GO GO:0031012; C:extracellular matrix; IDA:UniProtKB; . GO GO:0005576; C:extracellular region; TAS:Reactome; . GO GO:0005925; C:focal adhesion; IDA:UniProtKB; . GO GO:0042470; C:melanosome; IEA:UniProtKB-SubCell; . GO GO:0016020; C:membrane; IDA:UniProtKB; . GO GO:0030496; C:midbody; IDA:UniProtKB; . GO GO:0005634; C:nucleus; IDA:UniProtKB; . GO GO:0048471; C:perinuclear region of cytoplasm; IDA:UniProtKB; . GO GO:0005886; C:plasma membrane; IEA:Ensembl; . GO GO:0005524; F:ATP binding; IEA:UniProtKB-KW; . GO GO:0005509; F:calcium ion binding; TAS:UniProtKB; . GO GO:0050750; F:low-density lipoprotein particle receptor binding; IDA:MGI; . GO GO:0019903; F:protein phosphatase binding; IDA:MGI; . GO GO:0003723; F:RNA binding; IDA:UniProtKB; . GO GO:0046790; F:virion binding; IPI:UniProtKB; . GO GO:0031247; P:actin rod assembly; IDA:MGI; . GO GO:0036500; P:ATF6-mediated unfolded protein response; TAS:Reactome; . GO GO:0071318; P:cellular response to ATP; IDA:MGI; . GO GO:0030433; P:ER-associated ubiquitin-dependent protein catabolic process; IMP:UniProtKB; . GO GO:0043066; P:negative regulation of apoptotic process; IMP:UniProtKB; . GO GO:0034975; P:protein folding in endoplasmic reticulum; TAS:ParkinsonsUK-UCL; . GO GO:0015031; P:protein transport; NAS:UniProtKB; . GO GO:0006898; P:receptor-mediated endocytosis; TAS:Reactome; . GO GO:0043666; P:regulation of phosphoprotein phosphatase activity; IDA:MGI; . GO GO:0034976; P:response to endoplasmic reticulum stress; TAS:ParkinsonsUK-UCL; . GO GO:0001666; P:response to hypoxia; IDA:UniProtKB; . GO GO:0030970; P:retrograde protein transport; ER to cytosol; IMP:ParkinsonsUK-UCL GO GO:0051208; P:sequestering of calcium ion; NAS:UniProtKB; . GO GO:0002224; P:toll-like receptor signaling pathway; TAS:Reactome; . Gene3D 3.30.565.10; -; 2; . HAMAP MF_00505; HSP90; 1; . InterPro IPR003594; HATPase_C; . InterPro IPR019805; Heat_shock_protein_90_CS; . InterPro IPR001404; Hsp90_fam; . InterPro IPR020575; Hsp90_N; . InterPro IPR020568; Ribosomal_S5_D2-typ_fold; . PANTHER PTHR11528; PTHR11528; 1; . Pfam PF02518; HATPase_c; 1; . Pfam PF00183; HSP90; 1; . PIRSF PIRSF002583; Hsp90; 1; . PRINTS PR00775; HEATSHOCK90; . SMART SM00387; HATPase_c; 1; . SUPFAM SSF54211; SSF54211; 1; . SUPFAM SSF55874; SSF55874; 2; . PROSITE PS00014; ER_TARGET; 1; . PROSITE PS00298; HSP90; 1; .

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